A new surgical clip that dissolves and be absorbed by the body after a certain period of time has been developed by researchers at Kobe University. Clinical use of the clip is expected to be beneficial as it can reduce the rate of postoperative complications and minimize problems associated with diagnostic imaging.
The biocompatible clip was developed by a collaboration between the Division of Mechanics and Physics of Materials at the Kobe University Graduate School of Engineering and the Division of Hepato-Biliary-Pancreatic Surgery at the Kobe University Graduate School of Medicine.
Typpical surgical clips are currently made of titanium. As many as 30 to 40 clips may be used during a single surgical procedure.
Clips remain inside the patient’s body after the wounds are healed. The retained clips lead to diminished quality of computed tomography (CT) and MRI (magnetic resonance imaging) images around the wound and may cause complications.
The newly developed clip is 5 mm in size and made of a magnesium alloy. The alloy also contains calcium and zinc to improve its microstructure, ensuring fastening ability and formability, qualities required of materials to make clips.
Testing Safety and Functionality
Safety and function of the clip were investigated with in vivo studies. To evaluate the safety, an implantation study was conducted in a subcutaneous mouse model.
Very little gas was produced as the clip dissolved and there was no inflammation of the surrounding tissues after 1 to 12 weeks.
These results suggest that the clip is associated with very few adverse effects. Blood testing revealed that levels of magnesium and other substances in the blood were in the normal range after 12 weeks.
The volume of the implanted clip was reduced by almost half after 12 weeks. Therefore, the clip is likely to dissolve and exit the body within 1 year.
For evaluation of functionality, the clips were tested in a rat model in which the biliary duct, portal vein, hepatic artery, and hepatic vein were occluded with the clip and a partial liver was removed.
The rat had no problems during a monitoring period of 8 weeks, suggesting that the clip functioned properly. Micro CT scanning of the mouse and rat revealed that the quality of images was not degraded and organs can be observed.
Mechanical engineering professor Mukai Toshiji, who was involved in developing the clip, said:
“We will conduct further in vivo studies and a clinical study within 2 to 3 years. Kobe University works toward the development of new medical devices. We will continue to promote collaboration between the Graduate Schools of Medicine and Engineering.”
Top Photo courtesy Kobe University, Graduate School of Engineering, Communications Division